Moon Rover Challenge. An educational space robotics resource to teach programming and promote space careers at secondary education levels

Nowadays, space educational activities are essential in schools, in order to show the importance of space research and exploration in our daily and future life. Space related activities provides teachers tools and a fascinating context to get students involved in different disciplines which are ‘difficult’ for them. In addition, programming is one of the most important skills in technological areas. Space technology is full of programming, algorithms, and code. However, students’ perception is different because they think coding is difficult and they will not be able to program a satellite or a rover, so they are not very interested and motivated to learn to program. A widely useful tool to motivate students to learn programming is educational robotics, which uses physical robots and block-based programming interfaces to attract their attention. However, these robots are not accessible for all schools, and it is difficult to use robots in the online environment created by COVID-19. Therefore, online tools are becoming more and more important in education, because they make activities more flexible and accessible for schools and students. In this paper, we show an educational resource that used space robotics as a context achieving two main objectives: to promote space careers and teach and motivate high school students to learn how to program. We also show our conclusions and lessons learned, after implementing this project in two different situations. The students’ challenge is to control a Moon rover, which is on the Moon surface in order to fulfil a space mission. The activities can be performed completely online using an online simulation tool and block-based programming language. We tested the educational material in an online event with many high school pupils and also in a face-to-face lesson with pupils studying a technical module. The experiences and feedbacks were positive and allowed us to improve the initial activities. Moreover, the results show students are more interested in space careers after completing the challenge. Space robotics give us a perfect opportunity to introduce subjects such as programming, robotics, and technology to students. These areas will be essential in the future and we have to change perception of the space industry because it is fundamental for the development of space exploration and our societ

Documento de expertos sobre el uso de terapia combinada de metotrexato con terapias biológicas o terapias dirigidas a pacientes con artritis reumatoide

We aimed to develop recommendations for the management of methotrexate (MTX) when considering the combination with biological (b) or targeted synthetic (ts) disease modifying drugs (DMARDs) in rheumatoid arthritis (RA). Methods: Eleven experts on RA were selected. Two coordinators formulated 13 questions about the combination therapy of MTX with bDMARDs or tsDMARDs. A systematic review was conducted to answer the questions. Inclusion and exclusion criteria were established as well as the search strategies (Medline, Embase and the Cochrane Library were searched up to January 2019). Two reviewers selected the articles and collected data. Simultaneously, EULAR and ACR meeting abstracts were evaluated. Based on this evidence, the coordinators proposed preliminary recommendations that the experts discussed and voted in a nominal group meeting. The level of evidence and grade of recommendation was established using the Oxford Center for Evidence Based Medicine and the level of agreement with a Delphi. Agreement was established if at least 80% of the experts voted ‘yes’ (yes/no). Results: The systematic review retrieved 513 citations of which 61 were finally included. A total of 10 recommendations were generated, voted and accepted. The level of agreement was very high in all of them and it was achieved in the first Delphi round. Final recommendations cover aspects such as the optimal MTX dosage, tapering strategy or patients’ risk management. Conclusions: This document is intended to help clinicians solve usual clinical questions and facilitate decision making when treating RA patients with MTX in combination with bDMARDs or tsDMARDsDesarrollar recomendaciones sobre el uso de metotrexato (MTX) en combinación con medicamentos modificadores de la enfermedad (DMARD) biológicos (b) o sintéticos específicos (ts) en la artritis reumatoide (AR). Se seleccionaron 11 expertos en AR. Dos coordinadores formularon 13 preguntas sobre la terapia combinada de MTX con bDMARD o tsDMARD. Se realizó una revisión sistemática para responder las preguntas. Se establecieron criterios de inclusión y exclusión, así como las estrategias de búsqueda (se realizaron búsquedas en Medline, Embase y la Biblioteca Cochrane hasta enero de 2019). Dos revisores seleccionaron los artículos y recopilaron datos. Simultáneamente, se evaluaron los resúmenes de las reuniones EULAR y ACR. Con base en esta evidencia, los coordinadores propusieron recomendaciones preliminares que los expertos discutieron y votaron en una reunión de grupo nominal. El nivel de evidencia y el grado de recomendación se establecieron utilizando el Centro de Oxford para Medicina Basada en Evidencia y el nivel de acuerdo con un Delphi. El acuerdo se estableció si al menos el 80% de los expertos votaron «sí» (sí/no). La revisión sistemática recuperó 513 citas, de las cuales finalmente se incluyeron 61. Se generaron, votaron y aceptaron un total de 10 recomendaciones. El nivel de acuerdo fue muy alto en todas ellas y se logró en la primera ronda de Delphi. Las recomendaciones finales cubren aspectos como la dosis óptima de MTX, la estrategia de reducción o la gestión del riesgo de los pacientes. Este documento está destinado a ayudar a los médicos a resolver preguntas clínicas habituales y facilitar la toma de decisiones al tratar a pacientes con AR con MTX, en combinación con bDMARD o tsDMAR

Usefulness of bone turnover markers as predictors of mortality risk, disease progression and skeletal-related events appearance in patients with prostate cancer with bone metastases following treatment with zoledronic acid: TUGAMO study

Owing to the limited validity of clinical data on the treatment of prostate cancer (PCa) and bone metastases, biochemical markers are a promising tool for predicting survival, disease progression and skeletal-related events (SREs) in these patients. The aim of this study was to evaluate the predictive capacity of biochemical markers of bone turnover for mortality risk, disease progression and SREs in patients with PCa and bone metastases undergoing treatment with zoledronic acid (ZA). Methods: This was an observational, prospective and multicenter study in which ninety-eight patients were included. Patients were treated with ZA (4mg every 4 weeks for 18 months). Data were collected at baseline and 3, 6, 9, 12, 15 and 18 months after the beginning of treatment. Serum levels of bone alkaline phosphtase (BALP), aminoterminal propeptide of procollagen type I (P1NP) and beta-isomer of carboxiterminal telopeptide of collagen I (b-CTX) were analysed at all points in the study. Data on disease progression, SREs development and survival were recorded. Results: Cox regression models with clinical data and bone markers showed that the levels of the three markers studied were predictive of survival time, with b-CTX being especially powerful, in which a lack of normalisation in visit 1 (3 months after the beginning of treatment) showed a 6.3-times more risk for death than in normalised patients. Levels of these markers were also predictive for SREs, although in this case BALP and P1NP proved to be better predictors. We did not find any relationship between bone markers and disease progression. Conclusion: In patients with PCa and bone metastases treated with ZA, b-CTX and P1NP can be considered suitable predictors for mortality risk, while BALP and P1NP are appropriate for SREs. The levels of these biomarkers 3 months after the beginning of treatment are especially importantThis study was supported by Novartis Oncology Spai

Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)

Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters. Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs). Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001). Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio

How Confinement and Back to Normal Affected the Well-Being and Thus Sleep, Headaches and Temporomandibular Disorders

The COVID-19 pandemic is having negative consequences not only for people&rsquo;s general health but also for the masticatory system. This article aimed to assess confinement and its new normal impact on well-being, sleep, headaches, and temporomandibular disorders (TMD). An anonymous survey was distributed to a Spanish university community. Participants completed a well-being index (WHO-5), a questionnaire related to sleep quality (the BEARS test), a headache diagnostic test (the tension type headache (TTH) and migraine diagnosis test), and the DC-TMD questionnaire. Questions were addressed in three scenarios: before confinement, during confinement, and the new normal. A total of 436 responses were collected (70% women, 30% men). A reduction in well-being and sleep quality was recorded. Respondents reported more TTH and migraines during and after confinement. Overall, confinement and return to normal did not increase TMD symptoms, and only minor effects were observed, such as more intense joint pain and a higher incidence of muscle pain in women during confinement. Reduced well-being is correlated with sleep quality loss, headaches, and TMD symptoms. This study provides evidence that pandemics and confinement might have had a negative impact on population health. Well-being was strongly affected, as were sleep quality, depression risk, TTH, and migraine frequency. In contrast, the temporomandibular joint and muscles showed more resilience and were only slightly affected

Inline Combline Filters of Order N With up to N+1 Transmission Zeros

[EN] In this paper we describe several alternative inline implementations for combline filters with transmission zeros located both below and above the pass-band. A systematic design procedure is also presented using a lumped-element equivalent circuit. Following the design procedure that we propose, up to N+1 transmission zeros can be implemented with an inline filter of order N. The generation of the transmission zeros is explained physically in terms of mixed inductive and capacitive couplings. Several filters are also manufactured and tested. Good agreement between measured and simulated results is demonstrated thereby fully validating the new filter concepts.This work was supported by the Ministerio de Ciencia e Innovacion under Coordinated Project PID2019-103982RB-C41.Vague, JJ.; Rubio Garrido, D.; Fuentes-Pascual, MÁ.; Cogollos, S.; Baquero Escudero, M.; Boria Esbert, VE.; Guglielmi, M. (2021). Inline Combline Filters of Order N With up to N+1 Transmission Zeros. IEEE Transactions on Microwave Theory and Techniques. 69(7):3287-3297. https://doi.org/10.1109/TMTT.2021.3072370S3287329769

Plan de acción tutorial para alumnos de planes de estudio a extinguir en la Escuela Técnica Superior de Ingenierías e Informática y de Telecomunicación

Resumen tomado de la publicaciónDe todas las herramientas de las que dispone el sistema universitario para formar a sus estudiantes, la tutoría es la que presenta una mayor capacidad para dejar una impronta diferenciadora en los alumnos. Por desgracia, en el sistema universitario español esta herramienta tradicionalmente se ha utilizado de manera muy escasa, y normalmente de forma simbólica. En el curso 2010-2011 dejan de impartirse las asignaturas de primer curso de planes de estudio a extinguir en la Escuela Técnica Superior de Ingeniería Informática y Telecomunicaciones (ETSIIT) de la Universidad de Granada. El Plan de Acción Tutorial (PAT) que se presenta en este documento pretende, mediante un sistema de tutoría personalizada al estudiante, suplir la falta de la docencia presencial de las asignaturas desaparecidas al objeto de que el alumno las supere, mejorando, consecuentemente, el rendimiento académico del estudiante y, por consiguiente, el de las titulaciones que se extinguen.NavarraUniversidad Pública de Navarra. Biblioteca Universitaria; Campus de Arrosadia; 31006 Pamplona; Tel. +34948169060; Fax +34948169069; [email protected]

Plan de acción tutorial para alumnos de planes de estudio a extubguir en la escuela técnica superior de ingenierias e informática y de telecomunicación

De todas las herramientas de las que dispone el sistema universitario para formar a sus estudiantes, la tutoría es la que presenta una mayor capacidad para dejar una impronta diferenciadora en los alumnos. Por desgracia, en el sistema universitario español esta herramienta tradicionalmente se ha utilizado de manera muy escasa, y normalmente de forma simbólica. En el curso 2010/2011 dejan de impartirse las asignaturas de primer curso de planes de estudio a extinguir en Escuela Técnica Superior de Ingeniería Informática y Telecomunicaciones (ETSIIT) de la Universidad de Granada. El Plan de Acción Tutorial (PAT) que se presenta en este documento pretende, mediante un sistema de tutoría personalizada al estudiante, suplir la falta de la docencia presencial de las asignaturas desaparecidas al objeto de que el alumno las supere, mejorando, consecuentemente, el rendimiento académico del estudiante y, por consiguiente, el de las titulaciones que se extinguen

Experts document on methotrexate use in combined therapy with biological or targeted synthetic disease modifying drugs in patients with rheumatoid arthritis.

We aimed to develop recommendations for the management of methotrexate (MTX) when considering the combination with biological (b) or targeted synthetic (ts) disease modifying drugs (DMARDs) in rheumatoid arthritis (RA). Eleven experts on RA were selected. Two coordinators formulated 13 questions about the combination therapy of MTX with bDMARDs or tsDMARDs. A systematic review was conducted to answer the questions. Inclusion and exclusion criteria were established as well as the search strategies (Medline, Embase and the Cochrane Library were searched up to January 2019). Two reviewers selected the articles and collected data. Simultaneously, EULAR and ACR meeting abstracts were evaluated. Based on this evidence, the coordinators proposed preliminary recommendations that the experts discussed and voted in a nominal group meeting. The level of evidence and grade of recommendation was established using the Oxford Center for Evidence Based Medicine and the level of agreement with a Delphi. Agreement was established if at least 80% of the experts voted 'yes' (yes/no). The systematic review retrieved 513 citations of which 61 were finally included. A total of 10 recommendations were generated, voted and accepted. The level of agreement was very high in all of them and it was achieved in the first Delphi round. Final recommendations cover aspects such as the optimal MTX dosage, tapering strategy or patients' risk management. This document is intended to help clinicians solve usual clinical questions and facilitate decision making when treating RA patients with MTX in combination with bDMARDs or tsDMARDs

Cost of Venous Thromboembolic Disease in Patients with Lung Cancer: Costecat Study.

Patients with lung cancer (LC) are at significantly higher risk of developing venous thromboembolism (VTE), which may lead to increased use of health resources and the cost of management. The main aim of the study was to determine the cost of the management of VTE events in patients with LC treated with Low Molecular Weight Heparins (LMWH) in Spain. Costecat was an, observational, ambispective pharmacoeconomic study. Patients with LC, with a first episode of VTE (symptomatic or incidental) in treatment with LMWH, were recruited from six third-level hospitals and followed up for six months. Sociodemographic, clinical and resource use variables of VTE-related implications and its treatment were collected. Direct healthcare costs and direct non-healthcare costs were recorded. Data collection was documented in an electronic case report. Unit costs were obtained from national databases. Costs (€2018) were estimated from the healthcare perspective. Statistical analysis was performed using the statistical program R 3.4.3 version (30 November 2017). Forty-seven patients were included. Mean age was 65.4 years, 66.0% were male. The percentage of patients with LC who had metastatic disease was 78.7%. Twenty-three patients (48.9%) needed hospital admissions due to thromboembolic episode. Total average cost of patients with cancer associated VTE (CAT) was €109,696.6 per patient/semester. The hospitalizations represent 65.8% of total costs (7207.3 € SD 13,996.9 €), followed by LMWH therapy which represents 18.6% (2033.8 € SD:630.5 €). Venous thromboembolism episodes induce an economic impact on patients and healthcare systems. Direct healthcare costs are the major burden of the total cost, in which hospitalizations are the main drivers of cost